Detalhe da pesquisa
1.
Anti-Leishmania compounds can be screened using Leishmania spp. expressing red fluorescence (tdTomato).
Antimicrob Agents Chemother
; 68(1): e0050923, 2024 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38063403
2.
New 2-nitroimidazole-N-acylhydrazones, analogs of benznidazole, as anti-Trypanosoma cruzi agents.
Arch Pharm (Weinheim)
; : e2400059, 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38627301
3.
Anti-Trypanosoma cruzi Activity, Mutagenicity, Hepatocytotoxicity and Nitroreductase Enzyme Evaluation of 3-Nitrotriazole, 2-Nitroimidazole and Triazole Derivatives.
Molecules
; 28(22)2023 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38005183
4.
Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy.
Mem Inst Oswaldo Cruz
; 117: e210401, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35239945
5.
Fungi in glacial ice of Antarctica: diversity, distribution and bioprospecting of bioactive compounds.
Extremophiles
; 24(3): 367-376, 2020 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-32157393
6.
The heterologous expression of Escherichia coli MutT enzyme is involved in the protection against oxidative stress in Leishmania braziliensis.
Mem Inst Oswaldo Cruz
; 115: e190469, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32638832
7.
Leishmania infantum induces high phagocytic capacity and intracellular nitric oxide production by human proinflammatory monocyte.
Mem Inst Oswaldo Cruz
; 115: e190408, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32321156
8.
Aldo-keto reductase and alcohol dehydrogenase contribute to benznidazole natural resistance in Trypanosoma cruzi.
Mol Microbiol
; 106(5): 704-718, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28884498
9.
Ascorbate peroxidase overexpression protects Leishmania braziliensis against trivalent antimony effects.
Mem Inst Oswaldo Cruz
; 113(12): e180377, 2018 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30507997
10.
Overexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations.
Mem Inst Oswaldo Cruz
; 113(9): e180162, 2018 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30066751
11.
MyD88 Adapter-like (Mal)/TIRAP Is Required for Cytokine Production by Splenic Ly6CloTLR2hi but Not by Ly6ChiTLR2hi Monocytes during Trypanosoma cruzi Infection.
J Biol Chem
; 291(45): 23832-23841, 2016 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27646001
12.
Synthesis and biological evaluation of potential inhibitors of the cysteine proteases cruzain and rhodesain designed by molecular simplification.
Bioorg Med Chem
; 25(6): 1889-1900, 2017 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28215783
13.
Synthesis of Xylitan Derivatives and Preliminary Evaluation of in Vitro Trypanocidal Activity.
Molecules
; 21(10)2016 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27735872
14.
Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.
Antimicrob Agents Chemother
; 59(5): 2666-77, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25712353
15.
Molecular characterization of Cyclophilin (TcCyP19) in Trypanosoma cruzi populations susceptible and resistant to benznidazole.
Exp Parasitol
; 148: 73-80, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25450774
16.
In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures.
Mem Inst Oswaldo Cruz
; 110(4): 566-8, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26061148
17.
Deletion of the lipid droplet protein kinase gene affects lipid droplets biogenesis, parasite infectivity, and resistance to trivalent antimony in Leishmania infantum.
PLoS Negl Trop Dis
; 18(1): e0011880, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38236929
18.
New drug discovery strategies for the treatment of benznidazole-resistance in Trypanosoma cruzi, the causative agent of Chagas disease.
Expert Opin Drug Discov
; : 1-13, 2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38715393
19.
Evaluation and discovery of novel benzothiazole derivatives as promising hits against Leishmania infantum.
Chem Biol Drug Des
; 103(4): e14525, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38627214
20.
Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations.
Parasit Vectors
; 16(1): 167, 2023 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37217925